The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a structured master database that compiles available genotoxicity and carcinogenicity data for Ames positive chemicals originating from different sources. By using a harmonised format to capture the information, this database represents a powerful resource for data analysis that can be used to guide a thorough evaluation of genotoxicity and carcinogenicity. The database is intended as a resource for evaluating the predictivity of the Ames test for in vivo genotoxicity and carcinogenicity when considered alone or in association with in vitro mammalian cell assays (gene mutation and clastogenicity/aneugenicity) and for better characterisation of those cases where the Ames test leads to irrelevant ('false positive') results. The database may also serve as a platform for detailed structural characterisation of specific groups of compounds with or without carcinogenic or genotoxic activity. Available here is also the Carcinogenicity Genotoxicity eXperience (CGX) dataset, previously hosted in the Lhasa Limited Site.
- Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? II. Construction and analysis of a consolidated database
- Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity?: I. Reports of individual databases presented at an EURL ECVAM Workshop
- Carcinogenicity Genotoxicity eXperience (CGX) dataset ZIP
- Instructions on how to use the EURL ECVAM Genotoxicity and Carcinogenicity Consolidates Database of Ames Positive Chemicals application/pdf;type=pdf1x
- Landing page HTML
- Data di pubblicazione