EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database of Ames Positive Chemicals

The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a structured master database that compiles available genotoxicity and carcinogenicity data for Ames positive chemicals originating from different sources. By using a harmonised format to capture the information, this database represents a powerful resource for data analysis that can be used to guide a thorough evaluation of genotoxicity and carcinogenicity. The database is intended as a resource for evaluating the predictivity of the Ames test for in vivo genotoxicity and carcinogenicity when considered alone or in association with in vitro mammalian cell assays (gene mutation and clastogenicity/aneugenicity) and for better characterisation of those cases where the Ames test leads to irrelevant ('false positive') results. The database may also serve as a platform for detailed structural characterisation of specific groups of compounds with or without carcinogenic or genotoxic activity. Available here is also the Carcinogenicity Genotoxicity eXperience (CGX) dataset, previously hosted in the Lhasa Limited Site.